HLA-D associated alloantisera react with molecules similar to Ia antigens.
نویسندگان
چکیده
منابع مشابه
Cross-reactions between mouse Ia and human HLA-D/DR antigens analyzed with monoclonal alloantibodies.
Two mouse monoclonal anti-I-E/Ck alloantibodies (H7-8.26 and H10-81.10) directed against 2 distinct determinants of the specificity Ia-7 and 1 anti-I-Ak alloantibody (H8-15.9) directed against a public determinant common to the I-A subregion products of the H-2k, H-2b, H-2d, H-2q, and H-2ja haplotypes identified cross-reactive determinants on lymphoid cells from various mammalian species, inclu...
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Peptides bound in the groove of MHC class I molecules and detected by CTLs are not normally accessible to Ab. We now report that MUC1 peptides that are bound within the groove of MHC class I molecules (H2 and HLA) and that can be detected by CTLs can also be detected by anti-MUC1 Abs. mAbs to the middle and C-terminal regions of the class I-associated peptides but not to the N terminus were abl...
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After in vitro mixed lymphocyte culture, cytotoxic lymphocytes develop which have specificity for components of the main histocompatibility complex (MHC) 1 of the stimulating lymphocyte population (1, 2). The effector cells were found to be directed mainly against class I histocompatibility antigens, that is, the H2-K and H2D antigens in the mouse (3), and the HLA-A or HLA-B antigens in man (4)...
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متن کاملTherapeutic preparations of IVIg contain naturally occurring anti-HLA-E antibodies that react with HLA-Ia (HLA-A/-B/-Cw) alleles.
The US Food and Drug Administration approved intravenous immunoglobulin (IVIg), extracted from the plasma of thousands of blood donors, for removing HLA antibodies (Abs) in highly sensitized patients awaiting organ transplants. Since the blood of healthy individuals has HLA Abs, we tested different IVIg preparations for reactivity to HLA single antigen Luminex beads. All preparations showed hig...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1977
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.74.8.3533